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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

HHS-NIH11 PA-25-306
Posted: Dec 18, 2024 12:00:00 AM EST
Closes: 01/07/2028
Views: 12

Description

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Synopsis

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Eligibility

Eligible Applicants:
County governments State governments Independent school districts Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Others (see text field entitled "Additional Information on Eligibility" for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) City or township governments
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding Activity Categories

Education Environment Health Income Security and Social Services

CFDA Numbers

  • 93.113 - Environmental Health
  • 93.143 - NIEHS Superfund Hazardous Substances_Basic Research and Education
  • 93.172 - Human Genome Research
  • 93.173 - Research Related to Deafness and Communication Disorders
  • 93.213 - Research and Training in Complementary and Integrative Health
  • 93.233 - National Center on Sleep Disorders Research
  • 93.242 - Mental Health Research Grants
  • 93.273 - Alcohol Research Programs
  • 93.279 - Drug Use and Addiction Research Programs
  • 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health
  • 93.307 - Minority Health and Health Disparities Research
  • 93.361 - Nursing Research
  • 93.393 - Cancer Cause and Prevention Research
  • 93.394 - Cancer Detection and Diagnosis Research
  • 93.395 - Cancer Treatment Research
  • 93.396 - Cancer Biology Research
  • 93.399 - Cancer Control
  • 93.837 - Cardiovascular Diseases Research
  • 93.838 - Lung Diseases Research
  • 93.839 - Blood Diseases and Resources Research
  • 93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
  • 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research
  • 93.855 - Allergy and Infectious Diseases Research
  • 93.865 - Child Health and Human Development Extramural Research
  • 93.866 - Aging Research
  • 93.867 - Vision Research
  • 93.879 - Medical Library Assistance

Contact Information

Agency: National Institutes of Health
Contact: National Institutes of Health
Email: grantsinfo@nih.gov
Phone: 301-402-2541
NIH Grants Information
grantsinfo@nih.gov

Additional Information

Document Type: synopsis
Opportunity Category: Discretionary
Version: 5
Last Updated: Sep 04, 2025 02:04:19 PM EDT

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