Omics Phenotypes Related to Down Syndrome for the INCLUDE Project (X01 Clinical Trial Not Allowed)

HHS-NIH11 PAR-24-081

Posted: Dec 05, 2023 12:00:00 AM EST

Closes: 03/13/2026

Description

This Notice of Funding Opportunity (NOFO) invites applications to usethe NIH INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) to access resources to generate a large volume of integrated genomic and multi-omics data to facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. These data, and associated clinical and phenotypic data, will become part of the INCLUDE Project data resource for sharing with the research community. No funding will be provided directly to applicants under this NOFO. Applicants are encouraged to propose omics essays of existing biospecimens collected from individuals with Down syndrome and controls. The program will accept applications that propose whole genome sequencing, including both short-read and long-read, exome, epigenome, and transcriptome sequencing, as well as proteomic, metabolomic, and single-cell RNA sequencing and ATAC sequencing, when justified. The omics data and related phenotypic data will be deposited in a public INCLUDE Project controlled-access database.

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications to usethe NIH INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) to access resources to generate a large volume of integrated genomic and multi-omics data to facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. These data, and associated clinical and phenotypic data, will become part of the INCLUDE Project data resource for sharing with the research community. No funding will be provided directly to applicants under this NOFO. Applicants are encouraged to propose omics essays of existing biospecimens collected from individuals with Down syndrome and controls. The program will accept applications that propose whole genome sequencing, including both short-read and long-read, exome, epigenome, and transcriptome sequencing, as well as proteomic, metabolomic, and single-cell RNA sequencing and ATAC sequencing, when justified. The omics data and related phenotypic data will be deposited in a public INCLUDE Project controlled-access database.

Eligibility

Eligible Applicants:

Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Independent school districts Others (see text field entitled "Additional Information on Eligibility" for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Native American tribal governments (Federally recognized)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Funding Activity Categories

Health Income Security and Social Services

CFDA Numbers

93.121 - Oral Diseases and Disorders Research
93.172 - Human Genome Research
93.173 - Research Related to Deafness and Communication Disorders
93.865 - Child Health and Human Development Extramural Research

Contact Information

Agency: National Institutes of Health

Contact: National Institutes of Health

Email: grantsinfo@nih.gov

Phone: 301-402-2541

NIH Grants Information
grantsinfo@nih.gov

Additional Information

Document Type: synopsis

Opportunity Category: Discretionary

Version: 2

Last Updated: Mar 31, 2025 12:56:19 PM EDT

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